Experimental Vaccine Protect Cattle from Johne’s Disease

ARS scientists announced last week a new experimental vaccine to protect cattle from the bacterium that causes Johne’s disease. The disease is a chronic intestinal disorder that can cause diarrhea, weight loss, poor health and sometimes death in cattle. In the United States, Johne’s disease is most prevalent in dairy herds, costing the industry more than $220 million annually. Researchers created a so-called cocktail of four proteins from the bacteria to create the vaccine.

Encouraged by test results with mice, the researchers scaled up their efforts to produce the four proteins and combine them into a single vaccine “cocktail” that could be administered to calves. Trials with dairy calves indicate the vaccine did not disappoint, rendering the young animals immune to the disease over the course of a year of monitoring. The researchers note the need for additional efficacy trials and welcome collaboration with an industry partner to further explore the patented vaccine cocktail’s commercial potential.

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